Director, Lead Evaluation and Cellular Pharmacology - Janssen Pharmaceuticals - Beerse

Johnson & Johnson Family of Companies

Région

Beerse
Postuler
At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science.

Our Discovery Technology and Molecular Pharmacology (DTMP) organization is looking for a Director of Lead Evaluation and Cellular Pharmacology

  • Develop and execute High throughput cell-based assays to support Hit ID and hit triage
  • Deliver comprehensive SAR and compound profiling data package for Neuroscience (NS), Oncology (Onc), and Infectious Diseases & Vaccines (IDV)
  • Manage high-throughput imaging assay design, data generation, data analysis, new assay development and applications for biosignature and cell painting across Janssen therapeutic areas.
  • Lead phenotypic screening platform and single cell technology platform using physiologically relevant/translational models to impact Discovery programs from concept to NME
  • Manage CRO for compound profiling at Beerse
  • Demonstrated track record in leading multidisciplinary teams and imaging technology platform with strong publications in the related field.
  • Effectively interaction with leaders across TA biology and Chemistry leaders and other functional areas at Beerse.
  • This leader should collaborate with the Automation/IT/Compound & Data Management teams to streamline assay processes and provide rapid data packages to support ongoing projects.
  • The director should foster strong partnerships with the ML/AI team at Beerse to deliver cell painting and phenotypic screening data and assay capability.
  • The leader will lead the team to transition data into knowledge for complex targets using imaging techniques and phenotypic/multiplex readouts to support target validation, hit triage and multimodality characterization from concept to NME
  • The individual must also excel in communication and have strong interpersonal skills necessary to influence business decision and create a collaborative, multidisciplinary, and global environment.
  • The position is in Beerse, Belgium.

Key Responsibilities:

  • Operational accountability for SAR testing tree design and execution together with the project team leaders
  • Manage high content cell-based assay development and resource needs for all Tas in collaboration with other leaders at DTMP
  • Create a learning, collaborative environment across Lead Evaluation and Cellular Pharmacology team members
  • Participate in personnel development at all levels through talent acquisition, performance management, providing opportunities for high performers
  • Accountable for setting the strategy and tactics in collaboration with the leaders across other research sites to build strong assay suites and assay platforms from hit triage to lead optimization
  • Create a learning, collaborative environment across team members
  • Work with TA leaders to address SAR for on-going portfolio and support external collaboration/alliances
  • Manage and build complex screening model (i.e. translational models, coculture and 3D etc.) and bioassay platforms in the next two years and ensure portfolio impact
  • Maximize our investment and drive IT integration across DTMP capabilities and beyond


Qualifications
Qualifications:
  • Ph.D. in molecular or cell biology, or a related field, plus 12 years of industry or related experience is required.
  • Extensive experience in the areas of high throughput high content assay development and screen execution is required
  • Broad knowledge in some of the following technologies including luminescence/fluorescence-based cellular readouts, gene profiling, high content imaging, CyTOF® technology platform is required.
  • Knowledge in one or two therapeutic areas (including Neuroscience (NS), Oncology (Onc), and Infectious Diseases & Vaccines (IDV) is required
  • People management experience including both Ph. D., M.S., and B. S. scientists as direct reports is required
  • Working experience in high throughput assay development and assay execution using primary and cultured cells is required.
  • Hand-on experience on screening model design, cell based compound profiling, high content imaging assay automation and image data analysis is required
  • Understanding multiparameter algorithms to visualize and quantify the interaction of therapeutics in diverse cell populations is required.
  • Knowledge in optimization of translatable cellular assays for use in preclinical drug discovery research and compound characterization such as 2D co-cultures, spheroids, organoids or organs-on-a-chip is preferred
  • Demonstrates broad knowledge in the field of expertise i.e. microphysiological systems, 3D cultures, translational screening model development of complex in vitro systems for Discovery program testing tree is required
  • Working knowledge with data analysis and visualization software such as Prism, Genedata, and Spotfire is preferred
  • Target engagement assays and translational screening model experiences are required
  • Experience with industry level high throughput screening, automation and related data analysis is preferred
  • Additional knowledge with coculture, tumor cell lines, CRISPR technology, iPSC is preferred
Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.


Primary Location
Belgium-Antwerp-Beerse-
Organization
Janssen Pharmaceutica N.V. (7555)
Job Function
R&D
Requisition ID
2005845097W
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